Children and adolescents are more vulnerable and have been experiencing a heightened level of stress and anxiety due to the COVID-19 crisis. Hence, the UNESCO’s guide will deepen our understanding in this regard and help the education system to better respond to the mental wellbeing of students. The Guide will enable us to make significant progress towards sustainable psycho-social support system for all students, teachers and families, as well as address our collective objective of leaving no one behind and provide to all children and youth equitable opportunities for quality learning.